Harga Paket Umroh 2015 di Palembang Hubungi 021-9929-2337 atau 0821-2406-5740 Alhijaz Indowisata adalah perusahaan swasta nasional yang bergerak di bidang tour dan travel. Nama Alhijaz terinspirasi dari istilah dua kota suci bagi umat islam pada zaman nabi Muhammad saw. yaitu Makkah dan Madinah. Dua kota yang penuh berkah sehingga diharapkan menular dalam kinerja perusahaan. Sedangkan Indowisata merupakan akronim dari kata indo yang berarti negara Indonesia dan wisata yang menjadi fokus usaha bisnis kami.

Harga Paket Umroh 2015 di Palembang Alhijaz Indowisata didirikan oleh Bapak H. Abdullah Djakfar Muksen pada tahun 2010. Merangkak dari kecil namun pasti, alhijaz berkembang pesat dari mulai penjualan tiket maskapai penerbangan domestik dan luar negeri, tour domestik hingga mengembangkan ke layanan jasa umrah dan haji khusus. Tak hanya itu, pada tahun 2011 Alhijaz kembali membuka divisi baru yaitu provider visa umrah yang bekerja sama dengan muassasah arab saudi. Sebagai komitmen legalitas perusahaan dalam melayani pelanggan dan jamaah secara aman dan profesional, saat ini perusahaan telah mengantongi izin resmi dari pemerintah melalui kementrian pariwisata, lalu izin haji khusus dan umrah dari kementrian agama. Selain itu perusahaan juga tergabung dalam komunitas organisasi travel nasional seperti Asita, komunitas penyelenggara umrah dan haji khusus yaitu HIMPUH dan organisasi internasional yaitu IATA. Harga Paket Umroh 2015 di Palembang

Oleh IRWAN JULIANTO

Saco-Indonesia.com,- Satu demi satu misteri penyebab diabetes melitus tipe 2 mulai terungkap. Para peneliti Harvard School of Public Health (HSPH) baru saja memublikasikan temuan mereka bahwa ada satu jenis protein atau hormon khusus yang ditemukan dalam sel-sel lemak yang terbukti membantu mengatur bagaimana gula darah dikendalikan dan dimetabolisasi untuk energi di dalam hati. Ini dikatakan akan membuka salah satu jalan bagi pengobatan diabetes tipe 2 yang menjangkiti ratusan juta penduduk dunia.

Diabetes tipe ini tidak bergantung pada insulin dan terjadi pada orang-orang dewasa (adult onset), berbeda dengan diabetes tipe 1 yang bergantung pada insulin dan terjadi sejak bayi. Diabetes tipe 2 dapat didefinisikan sebagai suatu kelainan metabolik yang ditandai dengan tingginya kadar glukosa darah akibat terjadinya kekurangan dan resistansi insulin. Kemampuan sel-sel beta pankreas berkurang bahkan rusak sehingga pasien mulai mengalami diabetes, dengan gejala-gejala seperti banyak makan (polifagia), banyak minum (polidipsia), dan banyak kencing (poliuria).

Jumlah kasus diabetes tipe 2 hampir sepuluh kali lipat kasus diabetes tipe 1 yang terjadi karena kerusakan pankreas sejak bayi. Hingga sekarang diyakini bahwa kegemukan menjadi penyebab utama terjadinya diabetes tipe 2 pada orang-orang yang memang secara genetis sudah membawa gen pembawa penyakit ini.

Dua-tiga dekade lalu sudah diketahui adanya hubungan antara kegemukan dan diabetes tipe 2, tetapi belum jelas apakah kegemukan memicu diabetes jenis ini ataukah hanya mempercepat terjadinya. Riset di Amerika Serikat menunjukkan, orang-orang dengan obesitas tiga kali lebih mudah terjangkit diabetes dibandingkan dengan mereka yang tidak kegemukan. Makin tua seseorang, risiko terkena diabetes tipe 2 juga kian besar. Orang-orang berusia 65 tahun, misalnya, lebih mungkin terserang dibandingkan dengan mereka yang berusia di bawah 20 tahun.

Diabetes tipe 2 juga diketahui erat hubungannya dengan faktor keturunan. Jika dalam keluarga Anda ada yang mengidap diabetes, kemungkinan Anda terjangkit diabetes cukup besar.

Jika ayah atau ibu Anda dan kakek atau nenek serta bibi atau paman Anda menderita penyakit ini, peluang Anda mengalami diabetes tipe 2 mendekati 85 persen. Jika ayah dan nenek mengidap diabetes, risiko Anda cuma 60 persen. Jika hanya ibu yang menderita, maka 22 persen risikonya bagi Anda akan menderita pula.

Diabetes tipe 2 umumnya terjadi pada orang dewasa akibat perubahan gaya hidup, berkurangnya kegiatan jasmani, dan jenis makanan/minuman yang serba fast food dan soft drink. Namun, saat ini diabetes tipe 2 ditemukan juga pada anak- anak dan remaja di Asia.

Penyakit kronis ini diyakini menyebabkan usia harapan hidup bagi penderitanya sepuluh tahun lebih pendek dibandingkan dengan orang-orang non-diabetik akibat komplikasi penyakit jantung koroner, stroke, dan gagal ginjal. Diabetes tipe 2 juga menyebabkan kecacatan, seperti kebutaan akibat komplikasi retinopati dan meningkatnya risiko sebesar 20 kali amputasi tungkai bawah. Pengidap diabetes ini mudah lupa dan mengalami impotensi.

Multipatologi

Selama berpuluh tahun para peneliti dan dokter dihadapkan pada misteri: tidak semua orang yang kegemukan atau resistan terhadap insulin mengidap diabetes tipe 2. Bahkan, cukup banyak orang yang amat gemuk tak terserang penyakit ini. Para ilmuwan lalu berteori bahwa ada suatu faktor yang tak dikenal yang terlibat dalam metabolisme glukosa dalam hati, dan mungkin kehadiran atau absennya elemen ini, dapat menentukan siapa yang terkena diabetes tipe 2.

Dalam jurnal Cell Metabolism edisi 7 Mei 2013, para peneliti HSPH mengungkapkan, dunia ilmiah sudah lama mengetahui bahwa salah satu peristiwa kunci bagi berkembangnya diabetes tipe 2 adalah produksi glukosa yang tak terkontrol dari hati.

”Namun, mekanisme yang mendasarinya tetap masih sukar dipahami,” kata Gökhan S Hotamisligil, Kepala Departemen Genetika dan Penyakit-penyakit Kompleks, dan JS Simmons, profesor genetika dan metabolisme di HSPH. ”Kami sekarang berhasil mengidentifikasi aP2 sebagai suatu hormon baru yang dikeluarkan dari sel-sel lemak yang mengontrol fungsi kritis ini.”

Lewat percobaan dengan mencit di laboratorium memakai teknologi mutakhir ditemukan bahwa jika jumlah aP2 berlebih, timbullah diabetes. Sebaliknya, jika hormon ini diblok atau di- switch-off, produksi glukosa dari hati dapat dikontrol lebih baik sehingga manifestasinya berupa diabetes tipe 2 dan penyakit-penyakit metabolik lainnya pun dapat dicegah.

Kemampuan sebuah organ—dalam hal ini jaringan lemak—begitu langsung dan menentukan dalam mengendalikan tindakan organ lain, yaitu hati, amat menarik, kata Hotamisligil. ”Kami menduga sistem komunikasi antara jaringan lemak dan hati telah berevolusi untuk membantu sel-sel lemak memberi komando kepada hati untuk menyuplai tubuh dengan glukosa pada saat-saat terjadinya kekurangan nutrien. Betapa pun, ketika sel-sel lemak yang membesar kehilangan kendali terhadap sinyal ini karena kondisi obesitas, tingkat aP2 dalam darah naik, glukosa diguyurkan ke dalam aliran darah dan tidak dapat dibersihkan oleh jaringan-jaringan lain. Hasilnya adalah tingginya kadar glukosa darah dan diabetes 2.”

Guru Besar FK UI yang mendalami diabetes, Sidartawan Soegondo, menyatakan, temuan para ilmuwan Harvard ini merupakan sumbangan berarti bagi perkembangan ilmu kedokteran. ”Akhir-akhir ini saya mengajarkan bahwa diabetes tipe 2 adalah penyakit dengan multipatologi,” ujarnya ketika dihubungi pada Selasa (21/5). Kini, selain organ pankreas, diabetes tipe 2 diketahui pula dipicu juga oleh metabolisme sembilan organ lain, antara lain hati dan ginjal.

 

Sumber :Kompas Cetak/http://health.kompas.com/read/2013/05/22/06524140/Harapan.Baru.untuk.Terapi.Diabetes.Tipe.2
Editor :Liwon Maulana
Ada Harapan Baru untuk Terapi Diabetes Tipe 2

GREENWICH, Conn. — Mago is in the bedroom. You can go in.

The big man lies on a hospital bed with his bare feet scraping its bottom rail. His head is propped on a scarlet pillow, the left temple dented, the right side paralyzed. His dark hair is kept just long enough to conceal the scars.

The occasional sounds he makes are understood only by his wife, but he still has that punctuating left hand. In slow motion, the fingers curl and close. A thumbs-up greeting.

Hello, Mago.

This is Magomed Abdusalamov, 34, also known as the Russian Tyson, also known as Mago. He is a former heavyweight boxer who scored four knockouts and 14 technical knockouts in his first 18 professional fights. He preferred to stand between rounds. Sitting conveyed weakness.

But Mago lost his 19th fight, his big chance, at the packed Theater at Madison Square Garden in November 2013. His 19th decision, and his last.

Now here he is, in a small bedroom in a working-class neighborhood in Greenwich, in a modest house his family rents cheap from a devoted friend. The air-pressure machine for his mattress hums like an expectant crowd.

 

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Mike Perez, left, and Magomed Abdusalamov during the fight in which Abdusalamov was injured. Credit Joe Camporeale/USA Today Sports, via Reuters

 

Today is like any other day, except for those days when he is hurried in crisis to the hospital. Every three hours during the night, his slight wife, Bakanay, 28, has risen to turn his 6-foot-3 body — 210 pounds of dead weight. It has to be done. Infections of the gaping bedsore above his tailbone have nearly killed him.

Then, with the help of a young caretaker, Baka has gotten two of their daughters off to elementary school and settled down the toddler. Yes, Mago and Baka are blessed with all girls, but they had also hoped for a son someday.

They feed Mago as they clean him; it’s easier that way. For breakfast, which comes with a side of crushed antiseizure pills, he likes oatmeal with a squirt of Hershey’s chocolate syrup. But even oatmeal must be puréed and fed to him by spoon.

He opens his mouth to indicate more, the way a baby does. But his paralysis has made everything a choking hazard. His water needs a stirring of powdered food thickener, and still he chokes — eh-eh-eh — as he tries to cough up what will not go down.

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Mago used to drink only water. No alcohol. Not even soda. A sip of juice would be as far as he dared. Now even water betrays him.

With the caretaker’s help, Baka uses a washcloth and soap to clean his body and shampoo his hair. How handsome still, she has thought. Sometimes, in the night, she leaves the bedroom to watch old videos, just to hear again his voice in the fullness of life. She cries, wipes her eyes and returns, feigning happiness. Mago must never see her sad.

 

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 Abdusalamov's hand being massaged. Credit Ángel Franco/The New York Times

 

When Baka finishes, Mago is cleanshaven and fresh down to his trimmed and filed toenails. “I want him to look good,” she says.

Theirs was an arranged Muslim marriage in Makhachkala, in the Russian republic of Dagestan. He was 23, she was 18 and their future hinged on boxing. Sometimes they would shadowbox in love, her David to his Goliath. You are so strong, he would tell her.

His father once told him he could either be a bandit or an athlete, but if he chose banditry, “I will kill you.” This paternal advice, Mago later told The Ventura County Reporter, “made it a very easy decision for me.”

Mago won against mediocre competition, in Moscow and Hollywood, Fla., in Las Vegas and Johnstown, Pa. He was knocked down only once, and even then, it surprised more than hurt. He scored a technical knockout in the next round.

It all led up to this: the undercard at the Garden, Mike Perez vs. Magomed Abdusalamov, 10 rounds, on HBO. A win, he believed, would improve his chances of taking on the heavyweight champion Wladimir Klitschko, who sat in the crowd of 4,600 with his fiancée, the actress Hayden Panettiere, watching.

Wearing black-and-red trunks and a green mouth guard, Mago went to work. But in the first round, a hard forearm to his left cheek rocked him. At the bell, he returned to his corner, and this time, he sat down. “I think it’s broken,” he repeatedly said in Russian.

 

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Bakanay Abdusalamova, Abdusalamov's wife, and her injured husband and a masseur in the background. Credit Ángel Franco/The New York Times

 

Maybe at that point, somebody — the referee, the ringside doctors, his handlers — should have stopped the fight, under a guiding principle: better one punch too early than one punch too late. But the bloody trade of blows continued into the seventh, eighth, ninth, a hand and orbital bone broken, his face transforming.

Meanwhile, in the family’s apartment in Miami, Baka forced herself to watch the broadcast. She could see it in his swollen eyes. Something was off.

After the final round, Perez raised his tattooed arms in victory, and Mago wandered off in a fog. He had taken 312 punches in about 40 minutes, for a purse of $40,000.

 

 

In the locker room, doctors sutured a cut above Mago’s left eye and tested his cognitive abilities. He did not do well. The ambulance that waits in expectation at every fight was not summoned by boxing officials.

Blood was pooling in Mago’s cranial cavity as he left the Garden. He vomited on the pavement while his handlers flagged a taxi to St. Luke’s-Roosevelt Hospital. There, doctors induced a coma and removed part of his skull to drain fluids and ease the swelling.

Then came the stroke.

 

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A championship belt belonging to Abdusalamov and a card from one of his daughters. Credit Ángel Franco/The New York Times

 

It is lunchtime now, and the aroma of puréed beef and potatoes lingers. So do the questions.

How will Mago and Baka pay the $2 million in medical bills they owe? What if their friend can no longer offer them this home? Will they win their lawsuits against the five ringside doctors, the referee, and a New York State boxing inspector? What about Mago’s future care?

Most of all: Is this it?

A napkin rests on Mago’s chest. As another spoonful of mush approaches, he opens his mouth, half-swallows, chokes, and coughs until it clears. Eh-eh-eh. Sometimes he turns bluish, but Baka never shows fear. Always happy for Mago.

Some days he is wheeled out for physical therapy or speech therapy. Today, two massage therapists come to knead his half-limp body like a pair of skilled corner men.

Soon, Mago will doze. Then his three daughters, ages 2, 6 and 9, will descend upon him to talk of their day. Not long ago, the oldest lugged his championship belt to school for a proud show-and-tell moment. Her classmates were amazed at the weight of it.

Then, tonight, there will be more puréed food and pulverized medication, more coughing, and more tender care from his wife, before sleep comes.

Goodbye, Mago.

He half-smiles, raises his one good hand, and forms a fist.

Meet Mago, Former Heavyweight

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